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Learn more about gel injections

Why does gel injection rejuvenate the skin?
As you age, your skin tissues become thinner and deeper, turning into clear wrinkles, causing many of the visible signs of aging to occur on your face. These facial lines are around the mouth, nose, eyes and cheeks, so the signs of aging are more visible in these areas.
This lost volume can be compensated and smoothed wrinkles by injecting gel or using other methods of injecting skin fillers. Gel injections can be used to remove facial dimples, increase the volume of the lips, eyebrow lift and other cases that we will discuss in this article.

What is the gel used in gel injection?
To rejuvenate the skin, materials that have a gel-like structure, such as fillers, fillers, or skin volumizers, are used. Injections of skin fillers can be used under the skin to compensate for the lost volume, eliminate wrinkles, improve the shape of the surface curves (contours) of the face and body.
Every year, more than one million men and women use gel injections to rejuvenate their skin due to their reasonable costs and very low side effects. After Botox injections, dermal filler injections are the most widespread skin rejuvenation method in the world.

What are the uses of gel injection?
In short, skin fillers are used to fill in and remove facial wrinkles. Gels have a tremendous effect on facial wrinkles; But gel injections have many more uses for rejuvenation. In the following, we tried to point out most of the applications of gel injections for skin rejuvenation. Most gel injection applications are approved by the FDA (Food and Drug Administration). Some applications have not yet been approved by the FDA; But they have a lot of safety and impact.

FDA approved gel injection applications

Use gel for volume: Skin fillers can be used to highlight and increase the volume of the lips, chin and cheeks. Most people know this application as “prosthesis”.

Wrinkle gel injection: Used to remove wrinkles such as frown lines, forehead lines, lines around the lips and nose and laughter line.

Facial volume injection gel: Facial volume reduction is one of the most unpleasant effects of skin aging. This effect is usually seen on the cheeks, eyelids and lips. One of the most effective ways to compensate for the lost volume is gel injection. This method can be used to remove dimples and dark circles under the eyes, eyebrow lift and sagging skin on the face and neck.

Gel injection for hand rejuvenation: In addition to facial rejuvenation, it can also be used to rejuvenate the skin. Among the applications of dermal fillers for the body, only for rejuvenation and increase the volume of the back of the arms, FDA approved and other uses have not yet been approved.

Rhinoplasty gel injection: Correction of the shape of the nose without surgery is one of the interesting applications of this treatment method.

Gel injection applications not approved by the FDA:
The FDA has specific guidelines for approving medications and treatments that sometimes lead to non-approval. FDA disapproval of a treatment does not mean that it is inappropriate or dangerous. But FDA rules are approved by doctors around the world and should be followed.

Increase hip volume
Increase breast volume
Volume the legs
Inject the gel into the bones, tendons, ligaments and muscles

What are skin fillers made of?
Important Note In this section, be sure to check the FDA approval before injecting the gel. Note that FDA-approved fillers can only be purchased by dermatologists or plastic surgeons. Currently, the FDA has approved a variety of skin fillers that we use only in Behbod Clinic. FDA-approved fillers have the fewest side effects and their risks have been studied in large, long-term studies.

There are two general categories for skin fillers. One based on durability and the other based on their components. Read a combination of the two main categories of skin fillers below

Because most fillers are made from materials that are absorbed and destroyed by the body over time, they have a temporary effect. Only one permanent filler has been approved by the FDA and contains substances that are not absorbed by the body. Some fillers, in addition to bulking agents, contain lidocaine, which has been used to reduce the pain and discomfort caused by injections.
First, let’s look at temporary fillers that have more users

1. Temporary or absorbable fillers
Temporary fillers are made of hyaluronic acid, collagen, calcium hydroxyapatite, polylactic acid or body fat. Fat injection, which is a great way to rejuvenate and rejuvenate the skin in another article entitled “What is fat injection?” We have examined in detail. Fat is one of the skin fillers; But obviously it is not a gel injection. That is why we have introduced it in this article.

Collagen in rejuvenating fillers
One of the most important structural components of the skin and other tissues of the body is a protein called collagen. Collagen makes the skin firm and firm, and in stronger tissues such as bones or muscles, it strengthens them. One of the events of skin aging is the breakdown of collagen fibers.

The collagen used in gel injections is obtained from animal sources (usually cattle) or human cells. Collagen is very safe for injection into the skin and has few side effects. But the main problem is that they have a short shelf life and usually disappear between 3 to 4 months and have the lowest shelf life among fillers. For this reason, pure collagen fillers are less commonly used.

Hyaluronic acid
Hyaluronic acid is a sugary substance (polysaccharide) that is present in many tissues of the body such as skin and cartilage. When hyaluronic acid is mixed with water, it thickens and becomes gel-like. Due to the naturalness and structure of the gel, today hyaluronic acid is the most widespread and popular substance used in gel injections.

Injectable hyaluronic acid is usually produced in the laboratory with the help of bacteria or has an animal source and is extracted from poultry. The best hyaluronic acids are those that, through chemical reactions, change their structure to have a more lasting effect. Jellies made from this material last between 6 to 12 months.

Calcium hydroxyapatite
Calcium hydroxyapatite is a mineral found in our bones and teeth that, along with collagen, strengthens them. It is dissolved in a gel-like solution for injection and then used to remove skin wrinkles as well as rejuvenate the skin on the back of the hand. Gel injection with calcium hydroxyapatite has a long shelf life and is stable for up to 18 months. This material is not suitable for volumizing the lips.

Polylactic acid
Polylactic acid or PLLA is a synthetic, biodegradable polymer compatible with body tissues. This material is used to make absorbable sutures as well as bone screws. Gel injection with polylactic acid is done in the form of several injections over several months. The effect of this substance appears over time and usually after a few weeks and sometimes lasts up to 2 years.

2. Non-absorbable and permanent fillers
These fillers have many side effects and risks, so today the use of non-absorbable or permanent fillers has been greatly reduced. The low safety of permanent fillers has led to only one of them being approved by the FDA. However, other permanent fillers have EU and Australian approvals.

A very important point needs to be made here about CE or EU approval. CE certification means that in the manufacture of a drug, health rules are observed and the production process of the product is approved by the manufacturer. But CE certification does not confirm the effectiveness or side effects of a drug in the short or long term. But FDA approval guarantees this.

Note that only for deep wrinkles, gel injections using non-absorbable fillers are allowed. Permanent injection of fillers to remove surface wrinkles has been banned all over the world.

Polymethyl methacrylate (PMMA) granules
The only permanent filler approved by the FDA is polymethyl methacrylate or PMMA, and under its rules, it is only allowed to remove wrinkles around the lips (such as the laugh line). Of course, there are many uses for this form of gel injection. Some of the applications of this filler include the following:

Fill in wrinkles around the lips (FDA approved application only)
Eliminate acne scars
Filling the cavities created by the wounds
Volume the lips
PMMA is a synthetic and biodegradable polymer, but it is well tolerated by body tissues. When you inject a foreign substance into the body, the body may react to it. A clear example of this is the case with drug allergies, where, for example, a person develops severe allergic reactions after injecting penicillin. Therefore, in the production of drugs and therapeutic products that are to enter the body, the issue of their tolerance by the body’s cells is very important. PMMA is widely used in medical products due to its excellent compatibility with biological tissues, famous examples of which are bone cement and eye lenses.

Recommendations and care after gel injection
Products called ArteFill or Bellafill are the only FMA-approved PMMA fillers that are both a filler and are manufactured by the same company. Arthophiles contain very, very small balls (between 30 and 50 microns) made of PMMA. In addition, bovine collagen as well as lidocaine anesthetic were used to make this filler.

Complications of this type of gel injection usually resolve within 24 hours. Complications include bruising, swelling, itching, redness, and mild pain at the injection site. In rare cases, we see skin rashes, bumps, and sensitive skin in the long run.

Bullets Bullets under the skin or inside the lips cause applicants to worry about permanent gel injections. You should know that this complication has been seen in only 1% of patients in 5 years after gel injection. This problem will not be seen if the permanent gels are injected by an experienced surgeon.

Permanent gels that are not approved
Other permanent gels, such as silicone oil, are not popular around the world and are not approved by the FDA. That is why we refrain from talking about them.

What is the best brand and material for gel injection?
It is up to you to choose the gel in terms of durability as an applicant for gel injections, but it is better to leave the choice of the appropriate brand and material of the gel to the treating physician; Because this is a very specialized and difficult task and can only be done by a doctor.

At present, the injection of temporary hyaluronic acid gel is the most popular method of gel injection among clients and physicians because it is easier to inject these gels and they have very few side effects. In addition, treating the side effects and allergies caused by hyaluronic acid is very simple. If your body reacts badly to this substance, by injecting an enzyme called hyaluronidase into the treated area, all the injected hyaluronic acid can be eliminated.

An important guide for gel injection applicants
If you are planning to inject gel, there are some important things to keep in mind when choosing a gel brand or something that usually catches the minds of applicants.

First of all, you need to choose the right clinic for this. A clinic that has the necessary licenses from the Ministry of Health and also has an experienced and skilled treatment team. The large medical team, compliance with international standards and the laws of the Ministry of Health, as well as the use of the best gels available in Iran, are among the things that have made Behbod Clinic one of the best dermatology clinics in Iran.

After choosing the right clinic, you should see if gel injections are the best skin rejuvenation method for you. Skin condition, age, history of gel or Botox injections, general health, smoking and various medications are some of the things that can make you a suitable or unsuitable candidate for gel injections. A complete description including the types of fillers and suitable rejuvenation methods for your skin will be fully explained in a face-to-face meeting by a specialist doctor.

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